Benjamin Labérie defended his PhD "Plasma froid à pression atmosphérique : Rôle du champ électrique sur la migration cellulaire et étude d’un jet diffusif sur les marqueurs de la cicatrisation"

Congratulations to Benjamin Labérie who successfully defended his PhD "Plasma froid à pression atmosphérique : Rôle du champ électrique sur la migration cellulaire et étude d’un jet diffusif sur les marqueurs de la cicatrisation" on November 25, 2025.

Abstract :
Plasma medicine is a young field that shows great promise, particularly for the treatment of chronic wounds. Cold atmospheric plasma (CAP) allows to heal these highly problematic wounds. This effect has been well established : numerous clinical trials report the beneficial effects of cold plasma on healing. However, the causes are only partially understood.
Wound healing is a very complex phenomenon consisting of several phases, but CAP impact, which is specific to each phase, are known.
Nonetheless, while studies highlight the impact of CAP on various aspects of wound healing, the fundamental mechanisms at the cellular and molecular levels are much less understood.
This thesis tackle, the mechanisms of CAP positive effectss. We explored the effect of CAP on the mesenchymal migration of primary human fibroblasts and the underlying molecular mechanisms.
CAP was then decomposed in order to understand the origin of its beneficial effect.
The results show that individual migration becomes more efficient through the stimulation of Arp2/3 activity and that the syngergy between reactive oxygen species and the electric field produced by the plasma is responsible for this phenomenon.

Jury : 
– Mathieu Coppey 
– Eric Robert 
– Nofel Merbahi 
– Nicolas David 
– Anna Poleysskaya 
– Alexis Gautreau 
– Antoine Rousseau